ASI SponsorPaola de CandiaGiuseppe Matarese2020-09-172020-09-172017-12-01https://hdl.handle.net/20.500.13025/5118Life expectancy has considerably increased over the last decades. The negative consequence of this augmented longevity has been a dramatic increase of age-related chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis. Epidemiology is telling us there exists a strong correlation between the neuronal loss characterizing these disorders and metabolic dysfunction. This review aims at presenting the evidence supporting the existence of a molecular system linking metabolism with neurodegeneration, with a specific focus on the role of two hormones with a key role in the regulatory cross talk between metabolic imbalance and the damage of nervous system: leptin and ghrelin.neurodegenerationneuroinflammationmetabolismleptinghrelinArticle Journal10.1016/j.neuropharm.2017.12.0255a37d63a6c5e1b5a034b8ad3