Berisio, RRBerisioGranata, VVGranataVitagliano, LLVitaglianoASI Sponsor2020-09-172020-09-172004-01-01https://hdl.handle.net/20.500.13025/1459This article deals with the effects of proline hydroxylation on collagen triple-helix stability, an issue that is still under discussion. To investigate the structural determinants of triple-helix stabilization by hydroxyproline (Hyp), we here characterized spectroscopically triple-helix heterotrimers containing both chains of (Pro–Pro–Gly)10 and (Pro–Hyp–Gly)10. Results are discussed in relation to the various triple-helix stabilization mechanisms.journal article54dcce088580fe1368eeb090http://onlinelibrary.wiley.com/doi/10.1002/bip.20017/full54dcce088580fe1368eeb090