Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2S availability

Hydrogen sulfide (H2S), an endogenous volatile mediator with pleiotropic functions, promotes vasorelaxation, exerts anti-inflammatory actions and governs angiogenesis. Previously, the SH-containing angiotensin converting enzyme inhibitor (ACEI) zofenopril, has been identified as effective in preserving endothelial function and inducing angiogenesis among ACEI. Based on H2S donor property of the active metabolite zofenoprilat, the objective of this study was to evaluate whether zofenoprilat-induced angiogenesis was due to increased H2S availability.